Not so much the movie because it came out before the comics ended, which itself is a VERY anime thing so there’s some relation there, but most characters are oblivious to each other and their own situation.
Ramona is literally controlled by what is essentially a consumerist system that was created by a pretentious guy oblivious to other people as anything but objects to play with, Ramona copes but doesn’t escape it by drifting through life and not forming positive bonds with anyone. Scott literally rewrote ALL of his own memories with him as a hero as a coping mechanism against growing as a person which would have required coming to terms with who he is. He was actually a piece of shit thug who fought constantly for little reason and used people as props in his life, and that dissonance between his own delusions and reality keeps him from actually relating to other human beings.
Most of the rest of the cast, in particular Knives, are normal people who tried to become caricature personalities such as “cool groupie” or “leader of a band” which didn’t mesh with reality much better than Scott. Only by abandoning what they “should” be and just being what they are do they move on with their lives. Kim was left emotionally stunted where Scott left her.
Wallace and Scott’s sister are the only major characters that have managed to grow the fuck up by both disregarding the expectations of society and also managing to actually be part of it.
All basically Eva shit, where the entire cast are stuck in a position they can’t actually fulfil, are stuck as adult children, or have almost no ability to connect to other people left.