How about this. All children of Powerpuffs have super powers, both male and female. The new trio is around 9-10 years old.
Bubbles is a housewife. Lives a few blocks away from the professor. Bubbles' husband works in townsville stock exchange. They have two kids. Boy and Girl. Boy is still in Ms. Keane's class at pokey oaks.
Blossom is a liberal progressive socialite. Not SJW. Does lots of charity work. Could be the mayor or some other highly respected person in the city. She has lots of adopted children from the third world/exotic countries. Only one biological daughter with super powers. Blossom's daughter resents her parents because they spend so much time with their adopted kids and trying to save the world. Only became a PPG to upstage her mother.
Buttercup has only one kid. A daughter she had with Boomer the rowdyruff boy. Buttercup is a lazy single mom who barely does anything and prefers to sleep all day, unless she is personally disturbed.
Boomer the father of Buttercup's daughter lives out in the country with fuzzy lumpkins. Them two are great friends.
Brick is a Hippie traveling the world, periodically comes to townsville to visit his niece. Butch is an artist in cityville.
Mojo Jojo is a college professor. Teaching courses on evil science.
Him is trying to turn his 'grand daughter' boomer and buttercup' daughter evil.
All new villains. Return of some old one's too. Like the feminist who only wanted dollar coins.