The one thing about Rick and Morty that I would say is profound is the way characters see personal meaning in the face of objective meaninglessness and arbitrariness. Like Morty does in the first multiversal tv episode. Rick does have more of a problem with this, though, which I find interesting.
This is by no means deep, but it is a thought you do not see often in TV. Meaninglessness is the opposite of what tv stories are normally about and the way it is handled and transformed into a different kind of meaning in Rick & Morty fits perfectly at a time where the unprecedented visibility of the cognitive output of the world seems to dissolve everything into absolute meaninglessness. (The way Morty deals with it is the only sensible answer if you think about it; the other being radicalism and deliberately thinking in black and white)
Roiland and Harmon are no poetic geniuses or masters of storytelling (although Harmon is very good at it), but they have managed to find a good balance with this show, in a way I haven't seen before IMHO.