>>92136959She's sad and miserable but still keeps a happy expression on her face. She's not sad or happy, she's a little bit of both. Melancholic perhaps.
Her posture and her upward glance might also indicate a shy and timid nature with her. She sees the viewer as a friend, someone she can feel comfortable around. However she can't be completely comfortable around you as she still has her Doom Kitty with her.
Overall, Ruby appears to be her normal Gloomy yet happy self.