The nose, definitely. I can understand a slight reddish/pinkish tinge, but not full-blown red. It's really distracting.
I can sometimes understand nose coloring like in the style of Over the Garden Wall and Animal Crossing, cause it looks like raggedy anne/puppet-like. But when the art style gets closer to how humans actually look, it;s distracting for me and makes the character look like they have a cold