Nah, because that'd probably turn off fans, even the ones who don't want to be pandered to. Like if they killed off Marco for laughs, just because a lot of people expect him and Star to get together.
But that should definitely be done at times. For example, I think starting with Ludo in season 1 as the main villain, then introducing Toffee, made the show getting more of a plot more dramatic than starting with a serious villain would have, and I think that switch of expectations was done deliberately (because by the time Toffee showed up, even people who'd been expecting a plot were kind of at the point of accepting it as a purely episodic comedy).
I didn't mean shows will always pander, even though that's what I kind of wrote. What I meant was more that, a lot of the time, people can write the first season or so of a show completely in the dark about what fans will think, even though they may try to predict their reactions to things. At this point the show hasn't had any fanbase influence, because it was of course created before fans could see it at all.
But then, once they're aware of what fans are thinking, their writing process has the potential to change slightly. They may try to pander to keep them happy or go the other way to piss them off. Or even if they don't do either, they still can end up constantly wondering if their newer episode will please the fans, should it be more/less like earlier ones, etc.