I don't read much manga but I've seen most of the isekai animes and the only one of those based on the otome concept is 'My Next Life as a Villainess: All Routes Lead to Doom!' Despite her being the villain character from the game basically everyone falls in love with her, including the girls and her brother.
Other female isekai animes:>So I'm a Spider, So What
You can guess from the title what it is, but it's about as far from what you described as possible.>The Saint's Magic Power is Omnipotent
In this she is the super special Chosen One, but there's not much combat so far and multiple dudes are in love with her.>I've Been Killing Slimes for 300 Years and Maxed Out My Level
This is sort of a goofy all-female comedy; she is super powerful but she just uses her power to chill out. No romance, not much action.>Ascendance of a Bookworm
This one is actually really good although the concept sounds boring. A lot of what makes her special is that she uses her knowledge from our world, whereas most isekais forget the other world thing after the first episode. Magic does enter into it but it's balanced with her being sickly, from a poor family, etc. It goes more into worldbuilding, plot progression, and consequences of things than most. And no romance so far (she's a child!)