As mentioned, Peggy is a big Hillary supporter. When Hank puts his usual GOP sign out in his front yard (which is first for Jeb!, then for Cruz), Peggy decides to put her first political sign next to his, this time for Hillary. This causes a rift between them. As stated, Hank turns around eventually and puts out a sign for Hillary ("I'm With Her"), which Peggy points out is smaller than her sign.
Kahn and Ming are full on board the Trump Train. Kahn assumed Hank is also on board, because he's a "dumb redneck," but when Hank tells him he's "with her," Kahn laughs in his face and calls him a cuck, then tells Ming, who also calls him a cuck. Even Dale calls him a cuck for supporting Hillary (which Hank points out the irony), but eventually, Hank learns to not care. Kahn and Ming's support of Hillary winds up losing them money, and almost gets them deported when ICE mistakes them for Mexicans. This is sorted out by Peggy and Hank. Kahn and Ming drop their support of Emperor Trump, with Kahn noting he didn't build the wall anyway. As a sidenote, Kahn now has an Asian VA.
Ming has a rift with her parents over their rampant Trumpism. She turns to Bobby, but Bobby is actually on the Trump train as well, posting "dank Trump memes" in places like r/the_donald. This leads to Ming dumping Bobby and telling him to never talk to her again, which "redpills" Bobby and causes him to embrace the incel movement. Joseph is initially in with Bobby, but realizes quickly that the entire movement is toxic and self-defeating, and says he'd rather go back to liking women (which causes one of the incels in Bobby's group to call him a simp). It's ultimately Hank who steps in and talks some sense into Bobby, telling him that a real man respects a lady, and gets him to drop being a shitlord and apologize to Ming. They mend their relationship over his apology.