The question isn't yes or no, it's how difficult it would be.
Transformations(shrinking, growing, aesthetic and form transformations of all types, body swaps and gender changes)
Mind Control and Hypnosis
Simple personality traits or aesthetics(sharp teeth, gloomy edgy goths, mean girls, aggressive tomboys, shy girls, messy hair, robots or monster girls)
Bondage(upgrades to medium difficulty if you want actually fun or interesting positions.)
Temporary Amputations(robots and cyborgs, undead, creative uses of portals)
Visually mild forms of torture(tickling, shocks)
Yuri(Downgraded from Hard in the last half decade)
Inappropriate relationships(teen girl and much older man, teen girl and a much younger girl, teen girl and non-anthro talking animal, teen girl plus creature with tentacles)
Orgasm denial/General female sexual frustration
A consistent poly relationship between a small to medium sized group of slutty bisexual friends.
Clitoris over stimulation and torture