As said, it pays homage to its various sources of parody as much as it lampoons those same sources. The blood, sex and drugs, though absolutely present, aren't without reason and out of nowhere. They're well thought out and well presented as facts of life in a universe where "super science" is a thing, costumed supes are a thing and anthropomorphic sea mammals running a criminal syndicate in New York are a thing.
Furthermore, VB matures as it keeps going while other adult animation seems to regress.
Family Guy, for example, started off as a legitimately heart-warming cartoon sitcom but with a talking baby, a talking, alcoholic dog and silly cut-away gags. However, as time went on, it regressed into common occurences of potty humour, cringe humour and shock-and-awe humour.
VB started with cringe/shock/potty humour but as it progressed, they grew less and less common. Yes, there's still the occasional sex joke, such as the definition of what a 'Rusty Venture' is, but they're presented organically. Going with that example, the Rusty Venture sex act joke is presented as a conversation among people over what they've heard or guessed the act itself to be in much the same way you and your friends might do in the same situation.>>116700045
Hardly. Knowing the source material, such as JQ or various comics, helps in appreciating the series on multiple levels, especially when you see the attention to detail VB puts into it. For example, the character Wide Whale is a clear homage to DC's Tobias Wale but plays at him actually being a humanoid cetacean. Furthermore, he wears corduroy. Wide-wale is a type of corduroy fabric. It's silly, but it shows their attention to detail.
Having a high IQ or low IQ does not affect your enjoyment of the show at all and I doubt any of its fans would argue otherwise.