Rough guesses:
Black Widow:
Sets up F&WS and Thunderbolts. Yelena established as new Black Widow. Russian superheroes maybe teased as well.
Falcon & Winter Soldier:
Sets up Thunderbolts a bit more, introduces Madripoor, MCU Zemo becomes the Zemo from the comics during the course of the series, maybe he drops some folklore about Wundagore Mountain in Sokovia, maybe also Latveria tease.
Eternals:
Gaea appears first here, shown greeting the Celestials, such as Arishem the Judge, then meets Thor in TL&T. We see the Celestials sow the seeds for mutants in the MCU.
WandaVision:
Introduces Witches, Darkhold, and Chthon, setting up much of what follows in DSMOM, MK, and Blade. Introduces Wiccan and Speed. Monica Rambeau likely gets powers as a result of being hurled into dimensional energy. SWORD becomes aware of extra-dimensional threats.
Multiverse of Madness:
Stephen and Wanda become allies, Mordo goes nuts and summons Nightmare. Several Multiverse characters introduced. Strange and Witch will found the MCU Midnight Sons.
Moon Knight:
Marc Spector claims he is an avatar of Khonshu, telling SWORD that like the Scarlet Witch he too is an avatar.
Werewolf by Night Jack Russell seeks Marc's help. Introduces Werewolves. Dracula teased.
Story told through multiple perspectives of Spector's personalities; unreliable narrator.
Blade:
Blade seeks the Darkhold, and so does Dracula. We might see Kull the Conqueror and Varnae in a flashback. Introduces Vampires. Strange, Witch, Knight, Werewolf by Night also seeking Darkhold.
SWORD are now aware of Vampires due to the events of WandaVision.
Blade vs Dracula One on one fight.
Strange using the Darkhold to destroy Vampires?
Chthon disguising himself as Blade's mother to trick him into becoming Demogorge?
Thor Love & Thunder
JaneThor follows Loki into Thor's universe, and Beta Ray Bill from another perhaps. Thor meets Gaea.
Enchantress, Mangog, Set?