I think they're hit-and-miss, but I like most. Charlie, Vaggie, the reporters, and Nifty are all pretty solid character designs. Others can feel over-done.
Like Alastor with his weird ear-hair and mini-horns, and Pentious with all his surplus eyes and lines on his tail. They're ideas that might sound fun on paper but all the extra details risk bogging themselves down and probably don't lend themselves to long-term animation.