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I don't know how many comics in total but the longest I've read
>Batman and 'Tec stretching from the 70s to new 52
>Hellblazer (300 issues)
>Nightwing (153 issues + 30 new 52 issues) + B&R + aforementioned Batman issues + Grayson (haven't started on rebirth tho)
>Invincible (144 issues)
Not technically one series but all of it really does build off each other
>All Star Squadron + Infinity Inc --> 90s JSA --> Golden Age --> Johns' JSA --> Justice Society of America '07 (including the garbage after Johns' left, I got curious)
I've been wanting to try reading Flash from Carmine Infantino all the way up until Infinite Crisis and Bart becomes Flash but haven't had the time for it