This has always been my fan casting.
Watching the Office, Jim was always a smug prick, I always thought he'd make a good Reed because he's obsessive, manipulative and thinks he knows whats best for people.
Emily Blunt was up for Black Widow way back when, and Marvel usually keeps close ties. Plus, having a real husband and wife onscreen could capture how much working with your partner is such a bad idea.
Bruce Willis has done quite a bit of voice acting in the past, and honestly whenever I read Ben, it's always in his voice. Just imagine John McClane saying "It's clobberin' time!"
Zac Efron is no stranger to roids and having legions of obsessed girls. Just look at this picture and tell me it doesn't scream "Flame On!"
Everyone always picks Mads Mikkelson. But I like Nicholas Costau for Victor. Think back to Season 1 of Game of Thrones. He is capable, egotistical, and if you can pretend Latveria is Cersei Lannister - his reliance and exploitation is juxtaposed quite nicely.