Well, now that you mention it, the "Cleanse Clock" will probably become important, with Charlie challenging herself (and the others), to get the Hotel up and running (and successful) by the next yearly extermination.
Alastor would always bait the others (especially Vaggie) by doing something seemingly evil, only to reveal it to be either something innocent, or a necessary evil that he isn't proud of (or, at least, pretends to be), but would eventually tire of their "rivalry", and would try to lull Vaggie into a sense of security, only becoming openly antagonistic when everyone's guards are lowered - only for Angel Dust, of all people, to prove that the hotel IS successful, possibly through a sacrifice.
Husk and Niffty would be revealed to be accomplices of Alastor, with Husk being reluctant, but too apathetic to do anything about it, and Niffty actually being on board with Al's plans, partly out of insanity, and partly out of her personal adoration towards the man.
His "defeat" at Angel's hands would leave him sulking, but he would humbly admit defeat, sticking around, while still working against the Hotel from the shadows, and using it's defense as an excuse to get rid of rivaling warlords like Vox and Valentino.
He would try to wreck Charlie's and Vaggie's relationship, initially by trying to appeal to Charlie, and later, by trying to woo Vaggie, only to find opposition in the form of Angel Dust (who cares about the two girls enough to try to defend them from Al), and then later, by his own minions (mainly Husk, who finds his underhanded work too much to stomach, even for him).
Sir Pentious would become a recurring villain, at first increasingly desperate to destroy the Hotel, then possessively defending it against other Warlords, claiming it to be "His right" to destroy it.
666 News would continue to shit on the Hotel, most likely until one of the anchors (most likely Tom), seeking penance and absolution, checks in.