Minerva Mink will likely be dropped, and I honestly wouldn't mind. She was under-developed and no good for anything beyond being a background character. The bigger question is whether the playful bawdiness that gave us hello nurse and fingerprints will survive.
Buttons and Mindy will need to be reworked. People these days are probably too squeamish for babies in mortal danger gags.
Big question mark around Goodfeathers. Depends entirely on what age range they're aiming for.
I hope Hip Hippos get dropped. I get the joke, but as we often say around here, ironic shitposting is still shitposting. They're painful to watch.