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They're both the only one of their kind in their day to day lives, but Diana was raised on Paradise Island, and her people are still there. Her story is more "stranger in a strange land" mixed with "you can never truly return home", since she came to Man's world as an adult.
Clark is the opposite, he's raised as a human, learning about and coming to terms with the fact that he's not one of them, and moreover, that he's the last (or one of the last) of his species. Bits of the Moses story in there. But he's also profoundly human, and while both he and Diana are spreading messages of peace and Justice, he does it from the perspective of having lived as a man, while Diana approaches it from the outside in, as someone who has never lived among them, but loves them anyway
Not that they're consistently written like this or anything