Extremely so. Every single motivating factor of the crew is removed, except for Frenchies relation to Female (it is changed but the core is the same), and Hughie losing his girlfriend (which is brought up in every single scene with Starlight). Butcher comes off as a loser, the Boys come off as incompetent twats put into troubles way by Butcher,
Hughie is carrying the team almost at all times, the supes sexual deviances are almost entirely removed except for two mentions of Doc Peculiar's place, Stillwell is a random corporate whore, no Terror, no Love Sausage, no Legend, Butchers wife is alive, so is her kid with the Homelander (not with black noir), Homelander is actually a likeable douchebag (when he isn't letting planeloads of people falling), and The Deep is a loser who wants to fuck dolphins.
I mean it's hard to cram up 80+ issues into one single season, but they are rushing forwards a lot while also changing so much stuff that the ending already cannot be the same as in the comic.