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The big issue is, Kamala is best known as a teenager. She hasn't really been tested in college stories like Spiderman has. That gives her limited shelf life.
We'll say you start at the absolute minimum of 14 years old for Kamala in her first movie. Her next movie comes out three yeats later, she's already 17 and about to exit high school. It's hard to pull off.
I guarantee if we get a third MCU Spidey, he'll be in college.