Shitposting aside, it's hard to compare the two because V&V only have one episode out, and LQ has a whole season, but I'll give it a shot.
Since it's a Netflix show, it allows for more serialized storytelling. With "deepest lore" shows like Gravity Falls, Adventure Time, etc, even if the creator wants to tell a big plot, the execs will want episodes to generally be standalone. Craig McCracken complained about it back when he was making Wander Over Yonder.
Since it's made by Mexicans instead of Chicanos, Mexican stuff is included (the bad guy is an Aztec god and they explore a native temple) but other cultures are visited in the show (in LQ the heroes travel around the world, while it seems V&V will mostly be confined to the city they live in.)
You ever get sick of "will they won't they" subplots where the protag is constantly spilling spagetti over his oneitus like Finn or Dipper or Wirt or Mordecai? Maybe V&V will have this with one of them pining for Mexican Wendy or the non-goth loli. In LQ the protag goes on a date with his waifu and kisses her in the first episode.
It's not perfect by any means though. The animation can be a little rough since it's made by Mexicans and the budget is modest. Plus, the first episode can be a little confusing to people because it's based off a preexisting series of movies, but it's also a soft reboot.
The theme song is a little better than V&V's too imo. https://www.youtube.com/watch?v=JtCmGtxo7Nw>>106290081
Why do I see this reaction image used on things that are barely edgy? Anon didn't even tell him to kill himself or call him an advertiser unfriendly term.