WITCH, Winx, Mysticons,Powerpuff Girls and My Little Pony did all of those things.
WITCH was good but it aired on Jetix and never became fully mainstream.
Winx's problem was that only the first three seasons are good.
MLP is taboo on this board for a variety of reasons.
Mysticons was one of the best cartoons of the decade, but it aired on Nicktoons and never became mainstream. A lot of people on /co/ dismissed it because it was 'Tumblr'.
Powerpuff Girls has been tainted by that awful reboot, so people have kind of forgotten that the original series was good.