>>102579984The show generally consists of a bunch of short, individual storylines that occasionally mesh with each other. Every now and then you get a larger arc but the focus is just the comedy from these characters interacting with the world around them.
Usually some Wario Land-centric stuff shows up for the show's bigger and more adventurous storylines, and you could have parts of Wario's history with the Mushroom Kingdom show up (like some disgruntled former minions from Mario Land 2 or Tatanga as Orbulon's friend)
The show occasionally takes time to parody and do pisstakes on the animation medium, much like how the games poke fun at Nintendo's business practices. Maybe have an episode where one of Wario's schemes makes them lose most of the animation budget so they have to keep making ads to get the money back, or one where members of the gang just don't feel like working so they just comment on previous episodes they weren't in. Ads for the show could consist of Wario just pasting his face on the main characters from other shows during their commercials and talking as them while doing fart noises for sound effects.
Waluigi is not a part of the main cast, but every now and then he'll show up to cause mischief, challenge the characters in contests, try to take over WarioWare, make things worse for everyone, and do general Waluigi things. He has no interest in joining WarioWare or being friends with anyone in Diamond City (except maybe Jimmy or Crygor), he just wants to do his thing and be a general pest.