Nah, to make a good deconstruction you have to make the characters feel like real characters and not parodies, and you also has to take up elements that are almost always forgotten or hidden on these kind of comics and the implications that exist if you take away the escapism element of it and use real life logic.
So instead of doing a plebcomic knockoff,you has to put some thought.
Like, these comics usually present the world as some kind of minority paradise. If you sesconstruct this, you can focus on the fact that most minorities fucking hate each other.
Or take the "tumblr" protagonist, and realize that the kind of people who do this kind of comic are usually very insecure and depressed, and are likely wearing a mask. BOOM, you just deconstructed it.
So a deconstruction of a tumblr comic could work as a bunch of characters living in a "paradise of acceptance full of gays", where people actualy hate each other if you look closely, and a place filled with people trying to hide their insecurities and self hatred on "quirkness". Add to that some theme about difficulties of early adulthood on the current times, and add some sympathetic main characters despite all this shit...and yes, you can have something interesting.