No longer an undead lich, her connection to her sword could be some latent spirit or soul possessing the sword, that forms a subconscious bond with her. Because Riot's into multiple souls inhabiting a single body for some reason, if the new Darkin and Aspect lore is anything to go by.
Her brother Zelos will be retconned out of existence. Pointless character that won't likely become a champion so why bother.
Father will be killed off by Noxian invaders instead of dying to some 'mysterious' disease.
Might be thrown into a lesbian relationship with Karma. Possibly Syndra but that's stretching it.
Strong potential to be Mary-Sue'd as Ionia's greatest war hero during the Noxian invasion. Not one of the greatest, but THE greatest - up there with Karma.