I really like the concept of vampires because the term is so malleable and can mean next to anything. Insectoid abominations like >>67813687
or existential abysses of time like >>67814951
, they can be shifted to fit what you need in a story.
Recently, I've really been captured by the so-called 'vampires' in Peter Watts' Blindsight novels (here they've been collected into the Firefall omnibus). I think they provide probably the creepiest interpretation I've heard just about ever, made so much more chilling because of the hard sci-fi position the novels take to do with transhumanism and space horror.
Essentially, they're this predatory subspecies of humanity stretching back to neolithic times, when they preyed on us from firelight until civilisation led to their eventual extinction. Biologically, they're essentially hyper-aware cannibals capable of long death-like hibernation, to maintain their satiety amid drooping human population levels. They were extremely territorial amongst themselves, and were capable of levels of abstract and predatory thinking which puts them far beyond the hypersensitivity of autistics. They were the author's depiction of a super-predator species adapted specifically to human beings. Even the way they looked - human from far away, but possessive of a malignant 'other' that to this day elicits a primal fear and revulsion in any human who sees them. Yes, they're the reason we're afraid of the night, and of the uncanny valley.
But they died out, once human beings developed architecture - something to do with their aforementioned autistic brains just couldn't handle such concentrations of uniform lines and perpendicular structure - places their prey now congregated. Hence, the 'cross hypothesis' that we recognise in pop culture today. It quite literally sent them into epileptic fits, and they became extinct. That is, until they are genetically resurrected some time in the near future as part of a wave of transhuman technological developments.