A handful of times. First time was when it came to powers for characters, I gave one character a beat angel escalayer based power boost.
I've later had rapey tentacle monsters, and a cult based loosely off of the shit from bible black.
Most recently I was thinking of stealing from one whose name I've forgotten sadly. The premise was some ancient witch was out studying when she got counterspelled/dispelled by orcs who had somehow developed powerful magic.
They proceed to rape her (to weaken her magic) and mindbreak her to get her to reveal her magical secrets to them.
While the rape orcs were pretty bogstandard and boring, it did make me think of taking a typical dumb brute race (ogres, trolls, or something along those lines) and having a fiercely intelligent mage among them allowing the dumb brutes to get around weaknesses that others normally use against them.
Figure that could be a curious idea for a game setting/plot.