Meh. DND always had its "epic combat" bullshit at higher levels (well, at least from ADND, I'd say, anyway 30+ years for sure) which isn't particulary different from le epic anime combat 101. Stylization, muh cosmic bullshit, mooks...
(hell, if anything nowdays fantasy anime tend to be more "low level" and have less of that. Biggest example would be Grimgar)
What is really different, regarding style which honestly is the "problem" if anything, is that DND is supposed to start very down to earth. I dare to say "realistic", even, in that the inn you start with would seem... hrm, would seem something you'd put in renassaince faire, if that makes sense. Your halfling has MAYBE seen a wizard doing a Gandalf impression with smoke and that's probably it, more or less.
Fantasy anime (and JRPGs) on the contrary very easily starts out high-magic, like the setting is more imbued in fantasy, magic and whatnot, and even the average guy protagonist is not nonplussed by it. Notice that something like Exalted does it by having the protagonists being basically Heracles, on the contrary, and this "high magic" is pretty present even in iyashikei fantasy anime.
There are many other thing that aesthetically seem off (most recurrent: the blend of magitech and "down to earth", the overeliance on dialogue during combat, the absence or modification of races, and let's say it, lolis and generally the "cutesy" attitude to sexuality) but aren't really a problem, I mean, if you really need your wizard to be a Louise clone it doesn't really go against the feeling of DND, if you ask me, cringey as it might be.
What might feel more distant to me is that generally fantasy anime (more than combat manga, even) has a subtext of interpersonal conflict that might be more at odds with DND than we would like to admit. The party is more than not a source of conflict as much as the villains, if they even are there. And this is not something new at all, remember Escaflowne?