Not even. There are certainly cards more self-destructive than in and we've had many topics about them (Sorrow's Path, Wood Elemental, etc) but as far as "useless" cards go I think there's a lot of room to be explored because you have to consider even ridiculous edge cases and decks where such a card could in theory be useful (such as Sorrow's Path, which while undeniably bad is also not totally useless).
The most useless card is probably Cabal Conditioning. It's a rare, meaning it can eat a rare slot in limited. It's best case scenario is that it causes your opponent to discard their hand but unlike Wit's End (also seven mana) it doesn't guarantee that they do so (though it does hit everyone in multiplayer). Its enormous mana cost means it can't be played until most players are top decking anyway.
Other cards I considered for the top prize:>Aladdin's Lamp (just because of the absurd mana cost and less than oppressive effect)>Divine Intervention (takes too long to pointedly not help you win the game)>Return of the Nightstalkers (high mana cost, self destructive effect, and only supports a handful of deliberately underpowered cards from an obscure starter set)