Playing a campaign in the Warframe Universe is actually a pretty cool idea as long as you treat warframes as they are show in the lore: a one in a thousand occurence in the vastness of space
Orokin technology is highly sought after, to the point that people are still trying to imitate and steal whatever they can to get an edge (Seer, Perrin dialogue)
You may be essentially human, but a human from earth isn't a corpus, a grineer, a martian, a cyborg from fortuna, an ice pirate from pluto, a servant of the main syndicates, or one of the more obscure ones...
Travel across the stars in hopes of making it !
Fly, cheat, sell, fight and steal your way across the cosmos ! There are litterally hundreds of ressources to fight for, and as many ways to customize your arsenal
Who will you side with ? Who will you antagonise ? And, most importantly, what will you do when the Grineer or the Corpus end up putting a bounty on your head, as other power players start to notice your presence ?
Who knows, you might even end up making trade deals with the tenno themselves. After all, they do pay well !