It's already been 'saved'. You adapt. Read something like the Southern Reach Trilogy. Or Three Body Problem. Our understanding now is vastly different from what it was 100 years ago, and it has revealed plenty of perfectly bleak concepts. You want new Great Old Ones? Personify the nightmares of physics. The tyranny of the light speed limit. The horror of quantum tunneling after maximum entropy happens. Black holes. Gamma ray bursts.
Or just go Delta Green - it's modern day and mankind no longer fears the Mythos, because it has BECOME it. Corporations are now newborn Great Old Ones. Mass human sacrifice happens constantly. Everyone is lusting for apocalypse and mass death to satisfy their suicidal and soul-dead wishes. The universe hates all life and wishes nothing good for it.
If you want to save cosmic horror, then stop fucking replaying and redoing Shadow Over Innsmouth. There's no horror left in decrepit towns full of dying lunatics with deformities, that's every single day for everyone now.