Tuca and Bertie is a show that targets a specific demographic that /co/ happens to be largely outside of. If you can't watch the show while making peace with that, then you're probably still going to hate it.
To argue for the show, however:
The appeal of Tuca and Bertie is that it's a fast paced, surreal cartoon sitcom that actually takes advantage of being a cartoon. It's sense of humor, world, and characters constantly use and brush off "cartoon logic" while also maintaining enough realism that the drama isn't undercut. The end result is something unique, especially when you consider the subject matters that carry the show's drama.
The show's comedy is middling in the beginning but it can hit some significant highs. Then from episode 3, I found that the show was developing enjoyable sentimental moments. Episodes 5+ contain fairly interesting character development that effectively replaces the middling humor, while still maintaining the show's humorous highs and general sincerity.
Then overall, I would say that the experience is nearly the opposite of something like Bojack Horseman. It's a lighthearted romp with a feelgood ending where things turn out all right.That said, it's a show that's for a rather specific niche, it's not unreasonable to dislike it.
It was a fun enough breath of fresh air, 7/10, mostly because I'm a sucker for surreal animation.