While both are sci-fi comedies, Rick and Morty focus a lot on alien humor, which is still fertile ground, while Futurama was 90% robot jokes that got stale within two seasons. Futurama kept beating that dead horse though, and then started raping its rotting carcass. It didn't help that the main character/mascot of Futurama was a robot. Imagine how terrible Rick and Morty would be with an obnoxious alien sidekick constantly flinging itself in front of the camera for attention and laughs every other scene and half of every season dedicated to this one character.
Rick and Morty also isn't afraid to make fun of tropes, particularly the shitty, "moral highground" ones that are just there to pat people on the ass and make them feel good. Morty always tries to do the right thing, or at least what would seem right if the writing was shallow as shit. Then Morty fails because it turns out that wasn't the right thing after all, as any more mature person might have seen from the start. etc.