Grodd. Wild brutal power with mind of evil genius, telepatic powers and army of intellectual brutes like himself. He can destroy your body with his animal might. He can destroy your mind with his alien/hyper-evolved/(choose your favorite version) brain. He can be very dangerous, it's not just "Haha talking monkey!" God, i hate normies.
But it already was on CW and it was good, so i choose the Rogues gang versus Flash. Ordinary human beings without powers, just gadgets and skill versus the superhuman. It's like many Luthors vs Superman, like evil Batmans vs anybody who is not Batman.