Ranma 1/2 is a terrible gender bender, but it is one of the funniest manga ever made. The gender bender enhanced the strengths of the manga, which is the humor aspect.
If more gender bender enhanced an already good work, then to would be an iconic gender bender like Ranma 1/2.
If you have an awesome drama about family problems, and a the son who just transformed into a girl exacerbates and escalates this drama, it does a good job. If it the comedic portion to ease the tension, it is terrible.